Industrial X-ray computed tomography (XCT) is a powerful tool for non-destructive characterization of materials and manufactured components. However, it faces significant challenges due to the complexity of internal structures, noise, and variability in resolution. Traditional computer vision models often struggle with noise, resolution variability, and complex internal structures, particularly in scientificimaging applications. State-of-the-art foundational models, like the Segment Anything Model (SAM)—designed for general-purpose image segmentation—have revolutionized image segmentation across various domains, yet their application in specialized fields like materials science remains under-explored. In this work, we explore the application and limitations of SAM for industrial X-ray CT inspection of additive manufacturing components. We demonstrate that while SAM shows promise, it struggles with out-of-distribution data, multiclass segmentation, and computational efficiency during fine-tuning. To address these issues, we propose a fine-tuning strategy utilizing parameter-efficient techniques, specifically Conv-LoRa , to adapt SAM for material-specific datasets. Additionally, we leverage generative adversarial network (GAN)-generated data to enhance the training process and improve the model’s segmentation performance on complex X-ray CT data. Our experimental results highlight the importance of tailored segmentation models for accurate inspection, showing that fine-tuning SAM on domain-specific scientific imaging data significantly improves segmentation performance. However, despite improvements, the model’s ability to generalize across diverse datasets remains limited, highlighting the need for further research into robust, scalable solutions for domain-specific segmentation tasks. Code and training data will be available in public.