We present Diffusion-KTO, a novel approach for aligning text-to-image diffusion models by formulating the alignment objective as the maximization of expected human utility. Unlike previous methods, Diffusion-KTO does not require collecting pairwise preference data nor training a complex reward model. Instead, our objective uses per-image binary feedback signals, e.g. likes or dislikes, to align the model with human preferences. After fine-tuning using Diffusion-KTO, text-to-image diffusion models exhibit improved performance compared to existing techniques, including supervised fine-tuning and Diffusion-DPO, both in terms of human judgment and automatic evaluation metrics such as PickScore and ImageReward. Overall, Diffusion-KTO unlocks the potential of leveraging readily available per-image binary preference signals and broadens the applicability of aligning text-to-image diffusion models with human preferences.