Large language models have emerged as a promising approach towards achieving general-purpose AI agents. The thriving open-source LLM community has greatly accelerated the development of agents that support human-machine dialogue interaction through natural language processing. However, human interaction with the world extends beyond only text as a modality, and other modalities such as vision are also crucial. Recent works on multi-modal large language models, such as GPT-4V and Bard, have demonstrated their effectiveness in handling visual modalities. However, the transparency of these works is limited and insufficient to support academic research. To the best of our knowledge, we present one of the very first open-source endeavors in the field, LAMM, encompassing a Language-Assisted Multi-Modal instruction tuning dataset, framework, and benchmark. Our aim is to establish LAMM as a growing ecosystem for training and evaluating MLLMs, with a specific focus on facilitating AI agents capable of bridging the gap between ideas and execution, thereby enabling seamless human-AI interaction. Our main contribution is three-fold: 1) We present a comprehensive dataset and benchmark, which cover a wide range of vision tasks for 2D and 3D vision. Extensive experiments validate the effectiveness of our dataset and benchmark. 2) We outline the detailed methodology of constructing multi-modal instruction tuning datasets and benchmarks for MLLMs, enabling rapid scaling and extension of MLLM research to diverse domains, tasks, and modalities. 3) We provide a primary but potential MLLM training framework optimized for modality extension. We also provide baseline models, comprehensive experimental observations, and analysis to accelerate future research. Our baseline model is trained within 24 A100 GPU hours, framework supports training with V100 and RTX3090 is available thanks to the open-source society. Codes and data are now available at https://openlamm.github.io.