Abstract: Calibration of computational simulations of biological dynamics against experimental observations is often a challenge. In particular, the selection of features that can be used to construct a goodness-of-fit function for agent-based models of spatiotemporal behaviour can be difficult (Yip et al. (2022)). In this study, we generate one-dimensional embeddings of high-dimensional simulation outputs using causal dilated convolutions for encoding and a triplet loss-based training strategy. We verify the robustness of the trained encoder using simulations generated by unseen input parameter sets. Furthermore, we use the generated embeddings to estimate the parameters of simulations using XGBoost Regression. We demonstrate the results of parameter estimation for corresponding time-series experimental observations. Our regression approach is able to estimate simulation parameters with an average $R^2$ metric of 0.90 for model runs with embedding dimensions of 4,8,12 and 16. Model calibration led to simulations with an average cosine similarity agreement of 0.95 with experiments over multiple model runs for cross-validation.