Recent advances in the video question answering (i.e., VideoQA) task have achieved strong success by following the paradigm of fine-tuning each clip-text pair independently on the pretrained transformer-based model via supervised learning. Intuitively, multiple samples (i.e., clips) should be interdependent to capture similar visual and key semantic information in the same video. To consider the interdependent knowledge between contextual clips into the network inference, we propose a Siamese Sampling and Reasoning (SiaSamRea) approach, which consists of a siamese sampling mechanism to generate sparse and similar clips (i.e., siamese clips) from the same video, and a novel reasoning strategy for integrating the interdependent knowledge between contextual clips into the network. The reasoning strategy contains two modules: (1) siamese knowledge generation to learn the inter-relationship among clips; (2) siamese knowledge reasoning to produce the refined soft label by propagating the weights of inter-relationship to the predicted candidates of all clips. Finally, our SiaSamRea can endow the current multimodal reasoning paradigm with the ability of learning from inside via the guidance of soft labels. Extensive experiments demonstrate our SiaSamRea achieves state-of-the-art performance on five VideoQA benchmarks, e.g., a significant +2.1% gain on MSRVTT-QA, +2.9% on MSVD-QA, +1.0% on ActivityNet-QA, +1.8% on How2QA and +4.3% (action) on TGIF-QA.