As the number of AI systems keeps growing, it is fundamental to implement and develop efficient control mechanisms to ensure the safe and proper functioning of machine learning (ML) systems. Reliable out-of-distribution (OOD) detection aims to detect test samples that are statistically far from the training distribution, as they might cause failures of in-production systems. In this paper, we propose a new detector called TRUSTED. Different from previous works, TRUSTED key components (i) include a novel OOD score relying on the concept of statistical data depth, (ii) rely on the idea’s full potential that all hidden layers of the network carry information regarding OOD. Our extensive experiments, comparing over 51k model configurations including different checkpoints, seed and various datasets, demonstrate that TRUSTED achieve state-of-the-art performances by producing an improvement of over 3 AUROC points.