Data Science Network (DSN) is a non-profit based out of Nigeria that focuses its efforts on high impact research and capacity building of the next generation of African data scientists. The organization harnesses trans-disciplinary and transnational partnerships to create data driven solutions for public health, agriculture, public safety, education, inequality, among others. DSN’s unique organizational structure hinges on the flow of connections and resources among its Knowledge Centres, Enabling Centres, Supporting Centres, and Catalyzing Centres. The results from the organization’s unique model has won global awards from UNESCO, the Economic Computation Conference, and by the African Union as a reference point on home-grown African-centric approach to sustainable application of research practice to address social problems. The organization's structure and key performance indicators of DSN are discussed in this position paper.