The growing field of Human-centric ML seeks to minimize the potential harms, risks, and burdens of big data technologies on the public, and at the same time, maximize their societal benefits. In this workshop, we address a wide range of challenges from diverse, multi-disciplinary viewpoints. We bring together experts from a diverse set of backgrounds. Our speakers are leading experts in ML, human-computer interaction, ethics, and law. Each of our speakers will focus on one core human-centred challenge (namely, fairness, accountability, interpretability, transparency, security, and privacy) in specific application domains (such as medicine, welfare programs, governance, and regulation). One of the main goals of this workshop is to help the community understand where it stands after a few years of rapid technical development and identify promising research directions to pursue in the years to come. Our speakers identify in their presentations 3-5 research directions that they consider to be of crucial importance. These directions are further debated in one of our panel discussions.